COPD 치료를 받고 있는 68세 남자 흡연자
Intervention : tiotropium (anti-cholinergic bronchodilator)
Comparison : conventional therapy (salmeterol, SABA)
Outcome : COPD 악화에 대한 효과
(중략)
논문선택 이유
① RCT - evidence level Ia
② exacerbation 에 초점 (첫 진단 or Stable phase가 아니라)
③ Tiotropium과 기존 치료방법을 비교
disorders, and chronic obstructive pulmonary disease (COPD). Hypoventilation and oxygen desaturation deteriorate during sleep secondary to a decrement in ventilatory response to hypoxia and increased PaCO2. In addition, diminished muscle tone develops during the rapid eye movement (REM) stage of sleep, which further exacerbates hypoventilation secondary to insufficient respiratory effort.