Role of Blood Supply
Nutrition to parenchyma (brain cells).
Brain is completely dependent on oxygen supply - No O2 reserves.
Irreversible damage in 4-6 minutes if no oxygen
Brain requires 20% of O2 for 2% of body weight.
Brain requires glucose for energy
No ability to use fat
Remove carbon dioxide and waste-products from cells
Cerebral perfusion
> 60 ml/100gr min-1 in Gray matter
40
CATCH는 심장기형(Cardiac defect), 특이한 얼굴형태(abnormal face), 흉선형성부전(thymic hypoplasia), 구개열(cleft palate), 저칼슘혈증(hypocalcemia)의 약자로 이러한 임상양상을 보이는 환자들에서 공통적으로 염색체 22q11의 미세결실이 확인되었습니다(Wilson et al., 1993). CATCH22 증후군의 임상양상을 보이는 환자들은 과거