In 2006 to 2007, Hayakawa
Micromolar 수준의 potency로 PI3K 억제효과를 가지는 생리활성물질(Hit compound) 발견
->한자리수의 nanomolar lead(선도물질) 개발
Broad spectrum PI3K inhibitor 로서 쓰임.
PI 103은 세포투과적.
ATP 와 경쟁하는 경쟁적 kinase inhibitor 이다. 일반적으로 100nM에 효과나타남
PI103은 Class Ia PI 30kinase isoform,
Epidemiology and clinical manifestations
Chickenpox
- Rash, low-grade fever, malaise
- Benign to immunocompetent patient
- Skin lesion : Hallmark of infection
maculopapule -> vesicle, scabs
(over hours to days)
Trunk and face -> other areas of the body
- Immunocompromised patients: hemorrhagic based lesion
Age : 37
Sex : Male
Anorexia, vomiting, systemic edema
Onset)내원 1달전
1년전부터 체력이 떨어지고 쉽게 피곤
약 3개월 전부터 한약 복용
감기가 떨어지지 않아 감기약을 수시 복용함
체중은 1년전에는 1kg감소, 최근 한달 동안 부으면서 약 2kg가량 증가
소변량이 매우 적고 야뇨 3회
계단을 오를 때나 운동할
*’Nano’ means….
Nanometer: one billionth of a meter
Nano-: prefix comes from the Greek word for ‘dwarf’
Chemical, physical, and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles
1. THE PROBLEM.
Insensitive to changes doctors
-Health care today needs a fundamentally different approach and a new breed of leaders.
The biggest driver of rising costs is medical progress
-New drugs, new tests, new devices, and new ways of using them.
The explosion of knowledge is going off within a system
-It leads to redundant care and errors that raise costs and threaten quality.