fluorophore-conjugated antibodies.
Synaptophysin (red) and microtubule-associated protein 2 (MAP2; green) in mouse cortical neurons were fluorescently labeled with specific primary antibodies and Thermo Scientific DyLight 649-Conjugated Goat Anti-Rabbit or DyLight 488-Conjugated Goat Anti-Mouse Secondary Antibodies, respectively. Nuclei in both panels were labeled with Hoechst dye.
결과 아세틸콜린이라 는 신경전달물질의 결손이 나타남.
5) 기타 신경전달물질의 이상
Serotonergic neuron loss - Raphe nuclei
Noradrenergic cell loss - Locus ceruleus
Increased MAO-B concetrations
Dysregulated glutamate activity
6) Estrogen
-알츠하이머의 위험은 여성에서 더 높게 나타난다. Estrogen은 신경 성장을 증진하고
PARESTHESIAS(감각이상)
⦁Lesions of the somatosensory cortex and adjacent regions produce characteristic deficits referred to as cortical sensory loss.
⦁In addition to negative symptoms of sensory loss, lesions of the somatosensory pathways can cause abnormal positive sensory phenomena called paresthesias.
Posterior column-medial lemniscal pathways
⦁tingling
HUMAN LOCOMOTION
Human erect locomotion is unique among living primates, requiring the evolution of specific neuronal mechanisms, and the integration of neuronal subsystems involved in postural and locomotor control(Mori, Matusue, et all 1998;Dietz and Duysens 2000; Grasso, Zago et al 2000; Dietz 2003; Rossignol, Dubuc et al 2006)
(heredity), 음주(alcohol consumption), 뇌졸중 과거력(previous CVA), 비만, 경구용 피임약의 복용 등
3. 분류
1) 허혈성 뇌졸중 (ischemic stroke) : 75%
혈액순환 장애로 뇌 조직에 에너지와 산소 결핍, 주로 infarction과 selective neuronal necrosis를 일으킨다. 예후는 hemorrhage 보다 좋은 편이나 재발 위험이 높다.