경로의 첫 효소의 활성을 저해한다.
ex) alkaloid → dimethylallytransferase
-allosteric enzyme: 생합성 경로에서 최초의 반응 또는 분기점의 반응을 촉매하여 이 생합성 경로의 전체 대사물질의 합성을 제어.
① allostery: 두 개의 binding site, 모양 크기 charge가 다름.
active site: substrate binding site.
enzyme(activity increase or decrease) or phosphorylation of the transcription factor CREB.
Glucagon increases intracellular concentrations of calcium by a mechanism that depends upon activation of protein kinase A.
Increased intracellular calcium reinforce some cyclic AMP mediated actions of glucagon, particularly on glycogenolysis.
Ketogenesis
Ketogenesis is the process by which ketone b
Recommended carbohydrate intake
RDA = 130 grams per day
AMDR = 45–65% of calories
Daily Value (for 2,000 kcal) = 300 grams
Dietary Guidelines
Choose/prepare foods with little added sugar
Choose fiber-rich fruits, vegetables, whole grains often
Moderating sugar intake
Use less added sugar
Limit soft drinks, sugary cereals, candy
Choose fresh fruits or those canned in water or juice
regulating of carnitine palmitoyl transferase(CPT)-1 and acyl CoA oxidase(ACO) which are target enzyme of FA oxidation
It can be considered on that fact that in the WAT expression of PPARα is occurred but in the PPARα -/- condition expression of PPARα mRNA is not occurred.
PPARα+/+
PPARα-/-
Apetite 3
Decreased(32%)
Decreased(37%)
Weight
Lipopolysaccharides (LPS), also known as lipoglycans,
are large molecules consisting of a lipid and a polysaccharide
joined by a covalent bond; they are found in the outer
membrane of Gram-negative bacteria, act as endotoxins and
elicit strong immune responses in animals.
LPS is the major component of the outer membrane of
Gram-negative bacteria, contributing greatly to the structu