Genetic, i.e. heritable (even if there are no other cases in family).
2. It is primary myopathy (as defined by clinical, histologic, and EMG criteria).
3. No histologic abnormalities other than degeneration and regeneration of muscle fibers + reaction to those changes (infiltration by fat and connective tissue); no abnormal storage of metabolic products.
4. All symptoms are effects
서론
MHC?
- 모든 척추동물의 면역계와 자가면역에서 large gene family에 의해 암호화되는 세포표면분자
- 크게 ClassⅠ과 ClassⅡ 두 종류로 나뉨 ClassⅠ과 ClassⅡ 사이에 존재하는 Gene family를 ClassⅢ라 부름
MHC 작용 메커니즘
단백질 조각(항원)을 그 세포의 표면에 제시
위에 있는 T-cell이나 NK cell등
Glycoprotein that exists on surface of organs and causes hyperacute rejection
α1,3-Galactosyltransferase
Enzyme that transfer α1,3-Galactose formed inside cell to surface of cells
Solution of Problems that HAR Has.
1) Inactivation of complements
The way to insert genes that express complements repression factor
2) α1,3-Galactosyltransfe
hypersensitivity. Limited research has been conducted in this area, though some potential exists for a variant in the gene HSP70-HOM , whose protein is hypothesized to have direct involvement in the stimulation of an immune reaction to abacavir.
HIV VIRUS
Human Immunodeficiency Virus
RNA genome
Reverse Transcriptase
Glycoprotein gp120, gp41
CD4, chemokine receptor(CXCR4) binding
glycoprotein(22,500Da)
인간 interferon beta gene을 Chinese Hamster Ovary cells(중국 햄프서 난소세포주)에 transfection시켜 제조
Mechanism
BBB(Blood Brain Barrier)의 역할
-이물질이 뇌 안으로 침입하는 것을 막는 울타리 역할
MS 환자는 이러한 BBB가 손상되어 있음
Avonex가 BBB의 integrity를 향상 시켜 이물질이 뇌안으로