분야
pptx2.Hyperacute Rejection(초급성 거부반응)
-Mechanism of HAR
-Solution of Problems that HAR Has.
3.The Principle Of Transgenic Mini-Pig
4.Considerations
Up to 1.58milion people in 2015
6,000 people died every year in America due to insufficient organ.
Opening of New Medical Industry
In case of Islet transplantation market which expands fastest, it could grow up to 20 billion $.
It could extend the share of Heart, Cornea, Liver, Kidney Transplant.
Hyperacute Rejection(초급성 거부반응):
Hyperacute Rejection is Immune Reaction caused by complement of immune system
α1,3-Galactose
Glycoprotein that exists on surface of organs and causes hyperacute rejection
α1,3-Galactosyltransferase
Enzyme that transfer α1,3-Galactose formed inside cell to surface of cells
Solution of Problems that HAR Has.
1) Inactivation of complements
The way to insert genes that express complements repression factor
2) α1,3-Galactosyltransferase gene targeting (knock-out)
The way to delete the gene that expresses α1,3- Galactose
3) Competitive reaction enzyme
The way to express competitive enzyme using substrate that α1,3-Galactosyltransferase uses
