Definition
the body responds to a particular substance (called allergens) in an exaggerated fashion
antibody mediated hypersensitivity reaction
can occur in many parts of the body.
the antibodies produced by the immune response bind to antigens on the patient's own cell surfaces
either be intrinsic or extrinsic.
Defintion
Known as immune complex hypersensitivity.
Systemic or organ spe
Differential Diagnosis
Idiopathic Pulmonary Fibrosis
Honeycombing, exclusion of known causes
Silicosis
Upper lung, calcification of hilar lymph node
Sarcoid
upper lung, bilateral hilar lymphandenopathy
Hypersensitivity Pneumonitis
Diffuse reticulonodular infiltration, air trapping
Pathophysiology
Type III & IV hypersensitivity
Type III: immune complex mediated re
(1) no effective treatment
(2) lung transplantation
(3) smoking cessation
7) 예후
Factors influencing progression
① cumulative exposure to asbestos
② duration of exposure
③ type of asbestos exposure
3. 탄광부 진폐증 (Coal Worker's Pneumoconiosis)
1) 석탄분진을 흡입하여 발생
2) simple : opacity < 1 cm
test (+)
- delayed hypersensitivity ; 영유아기에 많고 allergin skin test 음성
- 유병률 : 5~10% (소아의 8~10, 성인의 2%)
- food allergy는 출생후 몇 년간 m/c, 나이가 들수록 감소
- 대부분의 아이들은 결국 food hypersensitivity에 tolerance 생김
- allergen 회피 후 1~2년이면 1/3에서 임상적 반응 사라짐(땅콩, 견과류, 생선, 조개류 등