ALS는 유전적으로 다양한 질병이다. 최소한 15개의 ALS 관련 유전자 부위가 밝혀졌고, 가족의 ALS의 약 30%에서 원인이 되는 유전자가 알려져 있다. 산발적인 유형에서는 근본적인 요인들이 잘 알려져있지 않다. 운동뉴런의 상처는 여러 병원성 경로의 복잡한 상호 작용을 통해 일어난다는 현재의 견해와 함
1. Bacteria(E.coli)
Advantage
Fast Growth rate
Cheap
Various cloning vectors
Disadvantage
Impossibility of posttranslational modification
Inclusion body
Only simple proteins
2. Yeast(S.cerevisiae)
Advantage
Large scale process
Cheap
partially possibility of posttranslational modification
Disadvantage
Shortage of cloning vectors
Overglycosylation
degradation of drugs from the nanocarriers does not take place.
Therefore, for drugs to be successfully delivered to their target, many factors such as its size, biocompatibility, target specific affinity, avoidance of reticuloendothelial systems, stability in blood, or ability to facilitate controlled drug release need to be considered during manufacture of the nanoparticles. Ideal conditions
Gram’s stain sensitivity = 60 - 90%
Depends on organism, experience, #
Culture sensitivity = 80 - 90%
Latex agglutination becoming more widely used due to simplicity and accuracy