Discovery of the iPS cell
Expect to solve the problems of ES cells
How to think?
Active factor(protein) in ES cells skin cells
Aug, 2006, Pro. Yamanaka ’s laboratory in Kyoto produced ‘pluripotent cells’
Nov, 2007, the first Human iPS cells
iPS cells are a type of pluripotent stemcell
artificially derived from a differentiated cell,
by inducing a “forced”
Mid-1800s - Beginning research of Embryo
1908 – ‘StemCell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stemcell
1981 - Embryonic stemcell
1998 - Human's embryonic stemcell
2001 – First human embryo cloning
(중략)
2.1 Adult StemCell - How?From Bone Marrow
HSCs and MSCs are rich in b
cell)와 B 세포(bone marrow)
동물체내에서 조직세포의 사이를 왕래하면서 혈액과 림프를 따라 순환하기도 하고 림프기관인 지라 및 림프절에 축적되기도 한다.
이러한 림프구에는 T세포(T 림프구)와 B 세포(B 림프구)로 구분을 하는데, 태아후기부터는 골수에 정착된 간세포(stemcell)의 일부가 흉
Stemcell calssification
1. Based upon location
Embryonic stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
cells. Nevertheless, callus cells are often considered similar enough for standard scientific analysis to be performed as if on a single subject. For example, an experiment may have half a callus undergo a treatment as the experimental group, while the other half undergoes a similar but non-active treatment as the control group.
Plant cell calluses may be made to differentiate into the specializ