effect will decrease overtime.
* DART trial (in uganda)
-Entebbe cohort: untreated control group
-> dramatic impact on survival rate
Upon antiretroviral therapy
1981-1992 : before the antiviral era
1996 : antiviral therapy actually began
-> much better response as the times go by.
Only about 25% of those in need of treatment currently receive it in the developing world.
Le
effective oral Covid-19 treatments : reducing hospitalization, and death. (Lack of resources)
Nirmatrelvir : severe acute respiratory syndrome coronavirus 2 main protease (Mpro) inhibitor with potent pan–human-coronavirus activity in vitro.
Ritonavir low dose 100mg (CYP3A inhibitor) : Enhancing nirmatrelvir pharmacokinetics (approximately five to six times in vitro 90% eff
Epidemiology and clinical manifestations
Chickenpox
- Rash, low-grade fever, malaise
- Benign to immunocompetent patient
- Skin lesion : Hallmark of infection
maculopapule -> vesicle, scabs
(over hours to days)
Trunk and face -> other areas of the body
- Immunocompromised patients: hemorrhagic based lesion