due to weakness of the heart muscle)
Diagnosis
The diagnosis of ischaemic heart disease underlying particular symptoms depends largely on the nature of the symptoms. The first investigation is an electrocardiogram (ECG/EKG), both for "stable" angina and acute coronary syndrome. An X-ray of the chest and blood tests may be performed.
Myeloperoxidase has been proposed as a biomarker.
1. 급성 심근 경색증 혈청 효소 변화
Serum Cardiac Biomarkers
(1) clinical significant
심근 손상의 직접적인 근거가 된다.(STEMI 후에 necrotic heart muscle에서 방출)
혈중에 분비되는 총량은 경색의 크기와 비례하며, intracelluar location,molecular weight, , local blood and lymphatic flow 에 따라 각각 방출되는 protein의 종류가 다르
없을 수 있다.
큰 범위의 심근 허혈이나 NSTEMI 발생할 경우, 제 3심음, 제 4심음,
식은땀, 차가운 피부, 동성빈맥, 저혈압, 심첨부 후수축기 잡음 관찰
심전도
- ST-depression, 일시적인 ST-elevation, or T-wave inversion
Cardiac Biomarker(CK-MB, troponin*)
상승하면 NSTEMI
사망 혹은 반복되는 MI 위험성이 높아진다
of oxidative phosphorylation. So H+ pumps transport protons to extracellular fluid to maintain normal cytoplasmic pH.
Thus, Tumor acidity is a specific tumor biomarker. pHLIP is pH-dependent molecule, so it detects the concentration change of proton. If pH is lower in extracellular surface, this molecule enters into phospholipid bilayer due to transmembrane part containing uncharged Asp by