task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
Abstract
Abacavir (ABC) is a nucleoside analog reverse trascriptase inhibitor (NRTI) used to treat HIV and AIDS. The pharmacogenetics of abacavir are relate to the human leukocyte antigen B (HLA-B) gene and its variant allele *57:01. This particular allele has been strongly associated with abacavir hypersensitivity. Limited research has been conducted in this area, though some potential exists
Histologically, the islets consist of three major and at least two minor cell types.
Beta cells, which synthesize and secrete insulin, make up about 60% of a typical islet.
Alpha cells are the source of glucagon, 30% of islet tissue.
Delta cell, which are less abundant, produce somatostatin.
F cells, which secrete pancreatic polypeptide.
Fifth cell type that secretes ghrelin.
Fifty cell typ
Nanoparticles for drug delivery
[내분비학] The Pancreatic Islets
