5.2 Drug Delivery System
5.2.1 Advantage of Nano-drug delivery system
By diagnosis, and for treatment, we need enhanced drug delivery system. Drug delivery system of these days is just eat and let it flow through the body. It is not good at efficiency. Because the digestive system sometimes digest and remove the drug before it reaches to the target.
For enhancing the efficiency of drug
Nanoparticles present possible dangers
- due to the high surface to volume ratio
pass through cell membranes in organisms
Smaller nanoparticles evinced increased cytotoxicity.
Self-assembly :
process that disordered system of components forms an organized structure or pattern
The device is switched on - >
the pump pushes ions across the lipid membrane,
sensor
The range of resonance frequency= 10~30 MHz
The detection limit = 10^-12 g for analyte molecules( according to Sauerbrey’s equation )
S A W
Surface Acoustic Wave sensor in which the acoustic wave on the surface of the piezoelectric crystal, launched and received on the same surface of the crystal.
The range of resonance frequency= 200~400 MHz
The detection limit of SAW
protein과 lipid로 이루어져 있는 unit membrane이다.
unit membrane은 약 7.5~10 nm 두께의 membrane으로 전자현미경으로 관찰시 세 층으로 구성되어 있다. 바깥판과 속판은 전자밀도가 높고 두께는 각각 2.5 nm 정도이고, 중간판은 투명하며 두께는 3 nm 정도이다. 현대에 와서 plasma membrane이 안팎의 두 protein층과 그 사이
1. Introduction
Cause of Death
암 환자의 병기별 생존율
2. Various Sensors
Nano material
Cantilever
Nanowire
3. Basic Principle
4. Fabrication method
3 Key Points
APTMS is coupled to oxygen plasma-cleaned Si N.W.
Aldehyde groups are coupled to mAbs.
Unreacted free Aldehyde groups are blocked by
reaction with ethanolamine