Mood is affected by the release of monoamine neurotransmitters including serotonin and norepinephrine.
Lack of neurotransmission at central serotonergic or noradrenergic synapses causes depression.
CRF and depression
Hyperactive HPA axis enhances CRF transmission in the hypothalamus.
Increased arousal, decreased appetite, decreased sexual behavior, and increased heart rate and blood pre