Neurophysiological property
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s.
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm o
Atopic Dermatitis
(Treatment & Medication)
Provide relief of inflammation of eczematous lesions. Ointment base provides moisturization. White petrolatum is useful to avoid potential sensitization to preservatives in water-based moisturizers.
Anti-inflammatory agents
Mild topical corticosteroid mixed in petrolatum.
Use 1% ointment 2-3 times daily
Apply sparingly to affected areas bid/tid
(disconti
지질혼합물
피부 각질층 성분과 유사
대부분 oil-in-water emulsion
AD (Atopic Dermatitis)
Ceramide 부족이 원인
Objective
An Open clinical crossover evaluation was conducted to investigate the effects in Atopic Dermatitis(AD) of a multi-lamellar emulsion(MLE) that contained pseudoceramide(PS-9S). - Control group : CMC (Commercial moisturizing cream : 5% urea)
Neurophysiological property
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of