Neurophysiological property
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s.
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm o
afferent C-fiber
diversity of cutaneous n.s
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Immunological abnormality
T cell defect
CD8 suppressor/cytotoxic T cell↓
↑IL-4, ↓IFN-γ
Induce CD23(low-affinity IgER) on B cells
Increased IgE synthesis
Sustained T cell activation
- Genetic factor
: Multifactorial inheritance
First degree에서 자궁내막증 발생시 Risk 7배 증가
- Immunological factor
: Immunologic clearance↓, cytokine(TNF-a)↑, Macrophage↑
5. 분류
American fertility society(AFS,1985)
* 기준 : ① implant의 형태,크기,깊이
② Adnexal adhesion의 유무 및 범위
③ Cul-de-sac 폐쇄의 정