afferent C-fiber
diversity of cutaneous n.s
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Immunological abnormality
T cell defect
CD8 suppressor/cytotoxic T cell↓
↑IL-4, ↓IFN-γ
Induce CD23(low-affinity IgER) on B cells
Increased IgE synthesis
Sustained T cell activation
fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itchfiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s.
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Histological alter
cell growth and toxicity than nature-identical Cer in intact CHK.
Two pseudo-Cer have no evidence of toxicity, skin sensitization, mutagenicity and neither skin nor eye irritation.
MLE (Multi-Lamellar Emulsion)
지방산, 콜레스테롤과 함께 유사세라마이드를 포함하는 지질혼합물
피부 각질층 성분과 유사
대부분 oil-in-water emulsion
AD (Atopic Dermatitis)
세포 등의 주변부, 특히 결합조직과 다른 조직이 접촉하는 상피의 기저판 밑에 모여 교원섬유와 연결한다.
Ⅱ. 결합조직의 구성세포
1. fibroblast(섬유모세포)
① macrophage와 함께 connective tissue 내에 가장 많이 존재한다.
② collagenous, reticular, elastic fiber를 만든다.
③ amorphous intercellular substance에서 glycosami