History of sulfonylurea
IPTP for typhoid fever(장티푸스) in early 1940s
Many patients died. – acute & prolonged hypoglycemia
Carbutamide
effective oral hypoglycemic
Firtst sulfonyluea hypoglycemic
WHAT IS GOUT
Gout
caused by abnormally elevated levels of uric acid in the blood (sUA *> 6.8mg/dL ) resulting in a build-up uric acid crystals throughout the body
* sUA :serum uric acid
Common Cold Flu
리노 바이러스, 코로나바이러스 등
200여종 인플루엔자 바이러스
콧물, 코 막힘, 목 아픔, 기침과 근육통
드물게 열 두통, 발열, 오한, 근육통과 같은 전신 증상이 목 통증과 기침
But most of them were unsuccessful because of their lack of efficacy a
Method
Study design
연구기간 : 2010/3 ~ 2011/12
표본추출 : randomization, stratification (→ had chronic hypertension or not)
실험의 실용성 : 각 환자의 antihypertensive drug 섭생법의 작용 여부, antihypertensive 치료의 타당성은 고려 안 함.
Double-blind trial
Study patient
만 18세 이상,
Had septic shock that refractory to fluid resuscitation
O
. 이 약물은 두통, 어지러움, 메스꺼움, 복통 등의 부작용을 지닌다. Zaleplon은 장기간 복용하는 약물은 아니다.
- Zolpidem Double-blind, placebo-controlled investigation of the residual psychomotor and cognitive effects of zolpidem-MR in healthy elderly volunteers., Hindmarch I, Legangneux E, Stanley N, Emegbo S, Dawson J, Br J Clin Pharmacol. 2006;62(5):538.