* Omalizumab (Xolair) is the 149 kDa, glycosylated antibody which is produced by an engineered CHO cellline. This recombinant humanized monoclonal antibody blocks the high-affinity Fc receptor of immunoglobulin E (IgE). It is used to treat patients with moderate-persistent to severe-persistent asthma.The product was approved in the EU in 2005, although it has been available in the US since 2
3. 암화에 의한 세포주 확립
동물세포를 이용한 연구 발전에 기여
4. Sato등에 의해 무혈청 배양법 확립
1960. 무혈청 배양 시도
1963-5(Ham) 혈청 공급 없이
CHO cell cloning
1970(Sato) 혈청 대신 호르몬
첨가 cellline 무혈청 배양
성공
Human embryonal kidney, SV40 and large T antigen transformed
cells especially.
First of all, we can raise a question on its efficacy. To make this new concept of curing cancer to be
widely available, a high NSC/tumor cell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express an enzyme, then
implanted the transduced NSCs along with a rat glioma cellline
Endothelial Cell Coculture Within Tissue-Engineered
Cardiomyocyte Sheets Enhances Neovascularization
and Improves Cardiac Function of Ischemic Hearts
Department of Cardiovascular MedicineInstitute of Health BiosciencesThe University of Tokushima Graduate School
Limitation
Lack of organ donors
Complications associated with immune
suppressive treatments
engine, it still needs to have both battery-powered motor and engine to generate enough power.
Clean Diesel
The diesel car has been recognized as the main culprit of air pollution, but people are beginning to understand the diesel car in a different way. The clean diesel engine has a mechanism of compressed air and blast, and it enables the engine to generate the same power as gasoline eng