stemcells especially.
First of all, we can raise a question on its efficacy. To make this new concept of curing cancer to be
widely available, a high NSC/tumorcell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express an enzyme, then
implanted the transduced NSCs along with a rat glioma cell
stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-repressents
& high tolerance
3 Co-stimulatory Drugs
*’Nano’ means….
Nanometer: one billionth of a meter
Nano-: prefix comes from the Greek word for ‘dwarf’
Chemical, physical, and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles
Enamel
√ Hard and white substance covering the teeth
√ The hardest and most highly mineralized
√ Protects the fragile underlying parts of the teeth
√ Covers the crown and supported by dentin
Component of enamel
√ 96% of enamel : mineral, water, organic material
√ contain two unique classes of proteins amelogenins and enamelins
√ The basic unit of enamel is called
drug delivery. At the same time, it is also required to retain the drug stability and ensure that early degradation of drugs from the nanocarriers does not take place.
Therefore, fordrugs to be successfully delivered to their target, many factors such as its size, biocompatibility, target specific affinity, avoidance of reticuloendothelial systems, stability in blood, or ability to facilitate