Development background
2. History of development
1960s
Discovery of colony-stimulating factors (CSF)
1980s
GM-CSF, M-CSF, G-CSF and multi-CSF
The human G-CSF was cloned
Usage for the treatment at first
1990s
first approval of Filgrastim by the US Food and Drug Administration
Launched Lenograstim
2000s
Launched PEG-filgrastim
Peptides are released by neurosecretory nuclei of the hypothalamus into the hypophyseal portal venous blood surrounding the pituitary which are the major controllers of GH secretion by the somatotropes.
balance of these stimulating and inhibiting peptides determines GH release, this balance is affected by many physiological stimulators (e.g., exercise, nutrition, sleep) and inhibitors of GH s
Histologically, the islets consist of three major and at least two minor cell types.
Beta cells, which synthesize and secrete insulin, make up about 60% of a typical islet.
Alpha cells are the source of glucagon, 30% of islet tissue.
Delta cell, which are less abundant, produce somatostatin.
F cells, which secrete pancreatic polypeptide.
Fifth cell type that secretes ghrelin.
Fifty cell typ
preservation technologies. Various modern technologies are applied to inhibit the growth of micro-organisms in food product as various food-spoilage micro-organisms are exit. Consequently, the techniques are so complicated and diverse to state in one paragraph. This report divides the methods into several categories, physical, biological, and chemical, and introduces each technology briefly.
degeneration and regeneration of muscle fibers + reaction to those changes (infiltration by fat and connective tissue); no abnormal storage of metabolic products.
4. All symptoms are effects of striated muscle weakness (heart and visceral muscles may also be involved).
5. Weakness becomes progressively worse (i.e. not static – vs. congenital myopathies, metabolic myopathies).