1.1.2. Cyclooxygenase-prostanoid cascade
Figure 1.1. Metabolism of arachidonic acid
Despite the diverse chemical structure of aspirin-like drugs, the antinociceptive effect of NSAIDs is mainly due totheir common property of inhibiting cyclooxygenases involved in the formation of prostanoids. Prostanoids areformed by most cells and act as autocrine and paracrine lipid mediators. They are n
induced in response to inflammatory factors and is expressed in premalignant lesions, including cervical tissues.
In this preliminary study, the variability of COX-2 overexpression in cervical premalignant lesions was assessed.
NSAIDs and COX-2 inhibitors show anti-cancer activities in many cancer cells.
Aspirin showed strongest inhibitory effects on viability and survival of YD-8
콜린성 수용체 등에 길항
Pharmacokinetics (ADME)
Absorption
Almost complete
경구투여 시 first-pass effect로 생체이용률 60-70%
Distribution
95%는 혈장단백질 결합
반감기 : 약 12시간
Metabolism
Cytochrome P450에 의해 대사
Norclozapine : pharmacologically active
CYP1A2 inducer : smoking
CYP1A2 inhibitor : theophylline, ciprofloxacin, fluvoxamine
effectively. The management can be transparent in that the ailing affiliates can be liquidated easily and people can recognize major shareholders well. Trading stocks also becomes much easier.
While changing the structure of company, LGE also tries to reduce the head office’s size to innovate. They disbanded many teams, including even ‘Blue Ocean’ team which have established creative strat
초래된다. 알코올의 중독 효과는 혈액 내 알코올농도가 내려갈 때보다는 올라갈 때 크다. 이러한 현상을 멜란비효과(the Mellanby effect)라고 한다.
흡수된 알코올은 전체의 약 10%가 신장과 폐를 통해 그대로 배설된다. 나머지 약 90%는 간에서 산화된다. 인체는 시간당 약 15dL를 대사한다. 이는 ethanol 12g,