Tretment
Tb에 대한 치료는 1940년대 스트렙토마이신의 발견으로 가능해 졌다. 무작위적 시험에서는 만성결핵을 가진 사람에게서 SM을 투여한 환자들이 mortality가 줄어듦이 알려졌다. 그러나 이 약 하나로 치료하는 것은 치료에대한 내성이 생기고 그리고 치료에 대한 실폐를 야기하게 되었다. PAS의 계발과
introduction
Detergent of laundry is closely related with our life and has been examined many times.
Currently using detergents
In enzyme detergent, most of enzyme is protease.
On the other hand, lipase is not commonly used.
Problem definition
Then, how about oily laundry?
laundry should be separated
laundry should be washed several
times.
Lipolase enzyme is reported
task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
혈중 glucose protease의 활성 증가
proinsulin → insulin + C chain
피하투여 했을 때 용해되는 시간을 좀 더 늘린 것
저녁을 먹기 전에 투여된 사람 insulin은 충분한 duration을 못가짐
아침에 혈당이 급격하게 저하
아침먹기전에 한번이나 하루에 두번 투여
TypeⅡ DM환자는 자기 전에 인슐린을 투여
resistant to trauma than normal
skin
v Thus, a higher recurrence rate exists after spontaneous closure than flaps
Lower extremity wounds (Venous)
v Valvular incompetence venous pressure increase edema with plasma
extravasation
v Fibrinogen leakage fibrin layer around the capillaries impairs oxygen and
nutrient diffusion
v Leukocytes may be trapped and activate