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분야
pptxII. INTRODUCTION
III. METHOD
MICRO-NEEDLES
SFM cantilevers
Mechanism
Apply or sense force through the displacement of a bendable beam(e.g. micro-needle, cantilevers, others)
Produces linear response over a broad range of displacement and forces
Size and shape – the two important factors that determine how a mechanical transducer interact with a single molecule or polymer
Acts molecules from a distance
Exerts force on molecules by either
Action on the molecule themselves
Or through “handles” such as glass beads, polystyrene beads or metallic particles attached to molecules.
exerts forces on objects through the transfer of momentum from the fluid to the object
Advatages
Liquids surrounding the tethered macromolecule can be easily replaced.
Flow can be used to introduce new beads or biomolecules
2. C. Bustamante, J.C.Macosko and G.J. L.Wuite: GRABBING THE CAT BY THE TAIL: MANIPULATING MOLECULES ONE BY ONE. Nature Nov. 2000, 130- 136.
3. http://coxem.kr/110002290215
4. http://www.youtube.com/watch?v=jCdnBmQZ6s
