Transitional cellcarcinoma (TCC) is a type of cancer that typically occurs in the urinary system: the kidney, urinary bladder, and accessory organs
It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus; it is the second most common type of kidney cancer.
TCC arises from the transitional epithelium, a tissue lining the inner surface of these hollow orga
bladder tumors are of epithelial origin, the remainder being mesenchymal tumors (Table 21-2). Most epithelial tumors are composed of urothelial (transitional) type cells and are thus interchangeably called urothelial or transitional tumors, but squamous and glandular carcinomas also occur. Here, we discuss the urothelial cell tumors in some detail and only touch on the others.
1. Urothelial (T
3. 암화에 의한 세포주 확립
동물세포를 이용한 연구 발전에 기여
4. Sato등에 의해 무혈청 배양법 확립
1960. 무혈청 배양 시도
1963-5(Ham) 혈청 공급 없이
CHO cell cloning
1970(Sato) 혈청 대신 호르몬
첨가 cellline 무혈청 배양
성공
Human embryonal kidney, SV40 and large T antigen transformed
1.1.2. Cyclooxygenase-prostanoid cascade
Figure 1.1. Metabolism of arachidonic acid
Despite the diverse chemical structure of aspirin-like drugs, the antinociceptive effect of NSAIDs is mainly due totheir common property of inhibiting cyclooxygenases involved in the formation of prostanoids. Prostanoids areformed by most cells and act as autocrine and paracrine lipid mediators. They are n
CellLine은 수명의 한계를 크게 가지고 그에 따라 생산량이 적을 수밖에 없다는 점이다. 바로 이러한 점을 해결하기 위한 노력이 불멸화 세포주를 만들게 된 가장 큰 이유일 것이다.
1.2. 불멸화 세포주의 필요성
거두절미하고 결론부터 말하자면 불멸화 세포주가 필요한 이유는 유용한 생리활성단백
cells of the epidermis)
표피를 구성하는 세포는 keratinocyte, melanocyte, merkel cell 및 Langerhan's cell이다.
(1) Keratinocytes
표피세포 중 keratinocyte가 가장 많이 존재하며 이 세포의 주된 기능은 표피의 protective 기능을 나타내는 fibrous 단백인 keratin을 생성하며 이들 세포는 desmosome이라는 구조로서 2 개의 세포가 단
Stem cell calssification
1. Based upon location
Embryonic stem cells
Somatic/ adult stem cells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
cell을 이용하게 되었다. 또한 신경 줄기세포의 분화 범위는 혈관 세포를 비롯하여 매우 다양하다는 특징과 Type I 당뇨의 근본적인 치료방법을 위한 시도가 증가하고 있는 사회적인 배경 또한 연구의 동기가 되었다.
실험의 과정은 다음과 같았다. 우선 사람의 뇌로부터 얻은 human neural progenitor cell을 in vi
1908 - The term "stem cell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stem cells.
1998 - James Thomson and coworkers derive the first human embryonic stem cellline at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
* Omalizumab (Xolair) is the 149 kDa, glycosylated antibody which is produced by an engineered CHO cellline. This recombinant humanized monoclonal antibody blocks the high-affinity Fc receptor of immunoglobulin E (IgE). It is used to treat patients with moderate-persistent to severe-persistent asthma.The product was approved in the EU in 2005, although it has been available in the US since 2