▦ Physiologic Action of Gut Hormones
Criteria
① Peptide must be related into blood during time that a biologic response in a target organ is being stimulated or inhibited
② IV infusion of pure natural peptide must reproduce the effect on target organ
③ Synthetic peptide should reproduce the effect found with natural peptide
④ Circulating concentration of peptide that cause stimulat
cyclicpeptides, furanosyl borate diester 구조를 가지는 auto inducer 들이 주를 이루는 것을 확인하였다.이 Quorum sensing 기작의 예 로 그람음성균인 Vibrio fischeri의 경우, LuxI 동족체들은 autoinducer로 알려진 AHL생산을 유도하며, 세균개체군이 증식에 수반하여 HSL이 일정수준 이상에 도달하면, LuxR 동족체들이 AHL과 결합
cyclic AMP
Activation of protein kinase A by cyclic AMP.
Phosphorylation of enzyme(activity increase or decrease) or phosphorylation of the transcription factor CREB.
Glucagon increases intracellular concentrations of calcium by a mechanism that depends upon activation of protein kinase A.
Increased intracellular calcium reinforce some cyclic AMP mediated actions of glucagon, particularly on
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
2. 펩티드
펩티드(peptide) ; 아미노산이 펩티드 결합에 의하여 연결된 화합물
수에 따른 분류 – 2개 ; 디펩티드 (dipeptide)
3개 ; 트리펩티드 (tripeptide)
여러 개 ; 올리고펩티드 (oligopeptide)
매우 많음 ; 폴리펩티드 (polypeptide)
<펩티드 결합>
글루타티온(glu