of PPARα+/+ and PPARα-/- mice
→ Food intake and weight are reduced in both mice
but fat is reduced only in PPARα+/+
Under the Hyperleptinemia condition fat disappears in 7 days without any relation which is about quantity of free FA or ketone
→ Thus WAT is transformed to Fat burning cells
Expression of PPARα causes leptin action by up-regulating of carnitine palmitoyl transfe
Introduction
BUT, How can we enhance
the Efficiency of Transgene Expression?
Regulation of Transgene Insertion
ZFN : fok1 restrict enzyme + Zinc Finger Protein
Fok1 restrict enzyme : recognition domain andnuclease domain are separated.
Zinc Finger Protein can recognize 9 base pairs.
ZFN can recognize 9 base pairs for each side by dimerization.
Specific sites can be cle
of power.
The APEC represents more than 60 percent of world’s internet users, also decided in 2002(reaffirmed in 2004) to adopt cyber-security regulatory measures, which follow the council of Europe cybercrime convention. The African union, in particular its African commission on Human and Peoples’ Rights adopted in 2002 a declaration of principles on Freedom ofExpression in Africa, which d
II. A contemporary human rights dilemma
As we mentioned earlier, China is not democratized as much as the other leading states in the international system. China’s internet censorship over its people by the central government can be seen as human rights dilemma in China, such as freedom ofexpression and privacy. China's internet regulations may be one of the most extensive and restrictive r
of depressed patients have supported a popular hypothesis for depression involving decrements in neurotrophic factors – neurodevelopmentally expressed growth factors that also regulate plasticity within adult brain. From a serial of depression patients’ decreased volume of hippocampus and other prefrontal region was observed. This supports popular hypothesis including decrease of neurotro