in this section we are going to
mainly focus on the limitations of neural stem cells especially.
First of all, we can raise a question on its efficacy. To make this new concept of curing cancer to be
widely available, a high NSC/tumor cell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express
invivo 유세포분석기(flow cytometer)를 이용한 CTC의 공초점 탐지는 2004년 처음 실행되었고 이동식 장치는 좀더 최근에 소개되었다. 그림 a에서 invivo 유세포분석기에서 탐지된 혈중 GFP 양성 다발성 골수종 세포를 보여준다. 측정은 종양세포를 주입한 후 다양한 간격으로 60초 이상 걸렸다(각 다른 3일간의 실
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
Liposomes
Liposomes are artificially prepared vesicles made of lipid bilayer.
Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases.
Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules.
Nano-particle drug carriers
Nano-particles are colloidal particles that range in size from 10 to 1000 nm i
*’Nano’ means….
Nanometer: one billionth of a meter
Nano-: prefix comes from the Greek word for ‘dwarf’
Chemical, physical, and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles