A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp
to thrombolysis
2) → conformational change inthe glycoprotein ⅡbⅢa receptor.
→high affirnity for the sequence arginine-glycine-aspartic acid on the fibrinogen gamma chain
→ platelet cross-linking and aggregation
B. coagulation cascade is activated(← damaged endothelium에서 tissue factor분비)
→ Ⅶ, Ⅹ activate
ofthe heart muscle, usually due to coronary artery disease (atherosclerosisofthe coronary arteries). Its risk increases with age, smoking, hypercholesterolaemia (high cholesterol levels), diabetes, and hypertension (high blood pressure), andis more common in men and those who have close relatives with ischaemic heart disease.
Symptoms of stable ischaemic heart disease include angina (chara
the drug molecules tothe target safely.
5.2.2 Nanocarriers - Nanoparticles
Before starting with the functionalization of nanoparticles, it is important to keep in mind a range of useful properties we wish to have in any drug delivery across the BBB(Blood brain barrier). In this context, owing totheir small size, customizable surface, improved solubility, targeted drug delivery and multi
16% to 22% of dizygotic twins.
Approximately the same or a slightly lower percentage of non twin brothers or sisters were homosexual
biological predisposition
slightly higher levels of testosterone or estrogen at certain critical periods of development
Variations in hormonal levels
structural differences inthe area ofthebrain
firms up between 18 month and 3 years
JOHN’s CASE