![[독성학] Atopic dermatitis-1](http://images.happyhaksul.com/thumb/388/387523-0001.gif)
![[독성학] Atopic dermatitis-2](http://images.happyhaksul.com/thumb/388/387523-0002.gif)
![[독성학] Atopic dermatitis-3](http://images.happyhaksul.com/thumb/388/387523-0003.gif)
![[독성학] Atopic dermatitis-4](http://images.happyhaksul.com/thumb/388/387523-0004.gif)
![[독성학] Atopic dermatitis-5](http://images.happyhaksul.com/thumb/388/387523-0005.gif)
![[독성학] Atopic dermatitis-6](http://images.happyhaksul.com/thumb/388/387523-0006.gif)
![[독성학] Atopic dermatitis-7](http://images.happyhaksul.com/thumb/388/387523-0007.gif)
![[독성학] Atopic dermatitis-8](http://images.happyhaksul.com/thumb/388/387523-0008.gif)
![[독성학] Atopic dermatitis-9](http://images.happyhaksul.com/thumb/388/387523-0009.gif)
![[독성학] Atopic dermatitis-10](http://images.happyhaksul.com/thumb/388/387523-0010.gif)
![[독성학] Atopic dermatitis-11](http://images.happyhaksul.com/thumb/388/387523-0011.gif)
![[독성학] Atopic dermatitis-12](http://images.happyhaksul.com/thumb/388/387523-0012.gif)
![[독성학] Atopic dermatitis-13](http://images.happyhaksul.com/thumb/388/387523-0013.gif)
![[독성학] Atopic dermatitis-14](http://images.happyhaksul.com/thumb/388/387523-0014.gif)
![[독성학] Atopic dermatitis-15](http://images.happyhaksul.com/thumb/388/387523-0015.gif)
![[독성학] Atopic dermatitis-16](http://images.happyhaksul.com/thumb/388/387523-0016.gif)
![[독성학] Atopic dermatitis-17](http://images.happyhaksul.com/thumb/388/387523-0017.gif)
![[독성학] Atopic dermatitis-18](http://images.happyhaksul.com/thumb/388/387523-0018.gif)
![[독성학] Atopic dermatitis-19](http://images.happyhaksul.com/thumb/388/387523-0019.gif)
![[독성학] Atopic dermatitis-20](http://images.happyhaksul.com/thumb/388/387523-0020.gif)
분야
pptpruritogenic mediators
Histological alteration
Immunological abnormality
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Immunological abnormality
T cell defect
CD8 suppressor/cytotoxic T cell↓
↑IL-4, ↓IFN-γ
Induce CD23(low-affinity IgER) on B cells
Increased IgE synthesis
Sustained T cell activation
