분야
pptx2.EU (European Union)
3.Issues
4.History of alternative to animal testing
5.The Anatomy of Human Skin
6.Artificial skin
7.Our target
8.Hair follicle
9.Strategies
Keratinocytes provide protective properties.
Melanocytes provide pigmentation.
Langerhans’ cells help immune system.
Merkel cells provide sensory receptors.
Dermis (2 layers)
Collagen, glycoaminoglycans, elastine, ect.
Fibroblasts are principal cellular constituent.
Vascular structures, nerves, skin ppendages.
Hypodermis (fatty layer)
Adipose tissue plus connective tissue.
Anchors skin to underlying tissues.
Shook absorber and insulator.
Advantages
- Made in large quantities and frozen for storage and shipping
- Artificial skin does not contain immunogenic cells such as
dendritic cells and capillary endothelial cells,
it is not rejected by the body.
- Rehabilitation time is significantly reduced.
- Alternative to animal testing
The problem of interaction between epidermis and dermis
Spontaneous blistering
2 step procedure
The application of various tests or treating diseases
Regeneration of sweet gland and follicle
