소개글
[생화학] 아밀로이드(Amyloid)와 프리온 단백질(Prion Protein) 매커니즘(영문)에 대한 자료입니다.
목차
PrPSC-Seeded fibril formation of recPrP
Concentration Dependence of PrPSc-seeded fibril formation
Discussion
Masel and colleagues
본문내용
Analyze the influence of concentraion to formation amyloid fibril
Varied the recPrP concentration
concentraion↑
Lag phase shoter
The increase in the steeper
Reaction saturated at a higher level
Varied the PrPSc concentration
concentration↓
Lag phase longer
The decrease in the steeper
Reaction saturated at a lower level
Together, these data indicate that the preamyloid state of PrP is partially denatured and otherwise α-helical, and exists as monomers and dimers.