A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp
Mid-1800s - Beginning research of Embryo
1908 – ‘Stem Cell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stem cell
1981 - Embryonic stem cell
1998 - Human's embryonic stem cell
2001 – First human embryo cloning
(중략)
2.1 Adult Stem Cell - How?From Bone Marrow
HSCs and MSCs are rich in b
Stem cell calssification
1. Based upon location
Embryonic stem cells
Somatic/ adult stem cells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
5. Science誌에 실린 황우석 교수의 연구 성과(1차 논문)
황우석 교수가 한 연구는 복제배아를 이용한 줄기세포를 이용해 난치병을 치료하는 것이다. 난치병의 예로 당뇨병이나 골 관절염 파킨스 병 같은 걸 들었는데, SCNT(somatic cell nuclear transfer)technology 를 이용해 환자의 DNA를 가진 stem cell을 만들어 낸
▦ Physiologic Action of Gut Hormones
Criteria
① Peptide must be related into blood during time that a biologic response in a target organ is being stimulated or inhibited
② IV infusion of pure natural peptide must reproduce the effect on target organ
③ Synthetic peptide should reproduce the effect found with natural peptide
④ Circulating concentration of peptide that cause stimulat